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A postdoctoral position is available in the Flick laboratory within the UNC Blood Research Center at the University of North Carolina at Chapel Hill. Individuals with experience in either cancer biology or coagulation/thrombosis and interest in interdisciplinary work to drive understanding in this exciting frontier are encouraged to apply. Anticipated work will include cell and molecular biology, mouse tumor and thrombosis models, and translational assays in clinical coagulation. Cancer biology and blood biology are inseparably linked. Cancer increases the risk of bleeding and inappropriate blood clots (thrombosis), both of which decrease quality and quantity of life. Ironically, recent success in cancer therapies has increased the incidence of clotting complications in patients with cancer. At the same time, we are becoming increasingly aware of the central contributions of blood and vascular cell clotting activity in cancer pathogenesis. Proteins traditionally associated with blood clot formation and composition, including fibrinogen, plasminogen, and tissue factor are major determinants of tumor growth and metastatic risk. Increased knowledge at the intersection of cancer and blood biology will enhance understanding of both fields.

Experience in mouse models of cancer and/or coagulation biology preferred. Working knowledge of mouse surgical techniques.